Identification of an Eight-lncRNA Signature as the Prognostic lncRNA Markers in Hepatocellular Carcinoma Patients

Long non-coding RNA (lncRNA) signature has been reputable for the predetermination of cancer prognosis. In present study, we constructed a lncRNA model to predict survival outcomes hepatocellular carcinoma (HCC) patients. Using transcriptome data from TCGA HCC samples, identified that NEAT1 and MALAT1 were highly expressed in other tumor subtypes compared adjacent normal tissues. Based on LASSO Cox regression model, an eight-lncRNA significantly correlated with overall disease-free training group. The prognostic value this was validated using test Further analysis suggested associated clinicopathological parameters such as vascular invasion, pathological stage, grade. Integrated functional showed these eight-lncRNAs involved cell cycle, metabolic process, immune response. conclusion, applicable is robust reliable prognosis HCC. This may provide efficient clinical prediction patients, further study required uncover function lncRNAs better.